Fresh analysis reveals that people who come off blockbuster slimming jabs like Wegovy and Mounjaro can put back on shed pounds at a significantly accelerated pace than those who halt conventional lifestyle programs.
Published data in a leading health publication points out that while overweight people frequently drop a large proportion of their body weight while on the medication, the weight is regained at an estimated rate of nearly a kilo each month after stopping.
"Users using such medications must be aware of the potential of rapid rebound weight gain when the treatment ends," warns researcher Dr. Susan Jebb.
That rate of recovery means a reversion to starting weight within about 18 months.
Analyzing Approaches
The research, which looked at dozens of trials involving thousands of patients, compared the outcomes of these new drugs with older methods.
The team emphasize that people who shed pounds through diet and exercise usually experience a slower creep back—perhaps 0.1 kg a month—after stopping.
The Reason for the Rapid Regain
Nutrition scientists propose the mode of action of the injections is key to understanding the amplified weight return.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which moderates appetite.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the system to generate a reduced amount of its own natural hormone, and may also lessen sensitivity to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this hormone supplement results in appetite is unsuppressed, making excessive eating a significant risk."
An Ongoing Issue?
Health authorities suggest the injections for people with obesity-related medical conditions, alongside recommended diet and exercise modifications.
A number of clinicians contend that, due to the likelihood of relapse, the therapy might need to be long-term.
This opinion is echoed by drug manufacturers, who say that the findings "highlight the chronic nature of obesity," similar to managing diseases like diabetes.
User Testimonies
People who have come off the jabs report a sudden return of cravings.
"It felt as if a switch that goes on and I was suddenly ravenous," described an individual.
This difficulty is exacerbated if patients have not adopted permanent lifestyle or habit changes during treatment.
Widespread Use
Survey data indicate that millions of people in the UK have tried these injections in the last 12 months, with demand being substantial.
- Use is more common among females than men.
- The middle-aged demographic shows the greatest usage rates.
- Many access the medications through private healthcare rather than the NHS.
In conclusion, clinicians caution that while these medications are effective agents for weight loss, they are not a standalone cure and lasting health benefits hinges on combined behavioural changes.
